Reassortment in segmented RNA viruses: mechanisms and outcomes
Identifieur interne : 000413 ( Main/Exploration ); précédent : 000412; suivant : 000414Reassortment in segmented RNA viruses: mechanisms and outcomes
Auteurs : Sarah M. Mcdonald [États-Unis] ; Martha I. Nelson [États-Unis] ; Paul E. Turner [États-Unis] ; John T. Patton [États-Unis]Source :
- Nature reviews. Microbiology [ 1740-1526 ] ; 2016.
Abstract
Segmented RNA viruses are widespread in nature and include important human, animal and plant pathogens, such as influenza viruses and rotaviruses. Although the origin of RNA virus genome segmentation remains elusive, a major consequence of this genome structure is the capacity for reassortment to occur during co-infection, whereby segments are exchanged among different viral strains. Therefore, reassortment can create viral progeny that contain genes that are derived from more than one parent, potentially conferring important fitness advantages or disadvantages to the progeny virus. However, for segmented RNA viruses that package their multiple genome segments into a single virion particle, reassortment also requires genetic compatibility between parental strains, which occurs in the form of conserved packaging signals, and the maintenance of RNA and protein interactions. In this Review, we discuss recent studies that examined the mechanisms and outcomes of reassortment for three well-studied viral families —
Url:
DOI: 10.1038/nrmicro.2016.46
PubMed: 27211789
PubMed Central: 5119462
Affiliations:
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Mcdonald</name><affiliation wicri:level="1"><nlm:aff id="A1">Virginia Tech Carilion School of Medicine and Research Institute, 2 Riverside Circle, Roanoke, Virginia 24016, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Virginia Tech Carilion School of Medicine and Research Institute, 2 Riverside Circle, Roanoke, Virginia 24016</wicri:regionArea><wicri:noRegion>Virginia 24016</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A2">Department of Biomedical Sciences and Pathobiology, Virginia–Maryland College of Veterinary Medicine, 205 Duck Pond Drive, Blacksburg, Virginia 24061, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Biomedical Sciences and Pathobiology, Virginia–Maryland College of Veterinary Medicine, 205 Duck Pond Drive, Blacksburg, Virginia 24061</wicri:regionArea><wicri:noRegion>Virginia 24061</wicri:noRegion></affiliation></author><author><name sortKey="Nelson, Martha I" sort="Nelson, Martha I" uniqKey="Nelson M" first="Martha I." last="Nelson">Martha I. 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However, for segmented RNA viruses that package their multiple genome segments into a single virion particle, reassortment also requires genetic compatibility between parental strains, which occurs in the form of conserved packaging signals, and the maintenance of RNA and protein interactions. In this Review, we discuss recent studies that examined the mechanisms and outcomes of reassortment for three well-studied viral families — <italic>Cystoviridae</italic>, <italic>Orthomyxoviridae</italic> and <italic>Reoviridae</italic> — and discuss how these findings provide new perspectives on the replication and evolution of segmented RNA viruses.</p></div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Maryland</li></region><settlement><li>College Park (Maryland)</li></settlement><orgName><li>Université du Maryland</li></orgName></list><tree><country name="États-Unis"><noRegion><name sortKey="Mcdonald, Sarah M" sort="Mcdonald, Sarah M" uniqKey="Mcdonald S" first="Sarah M." last="Mcdonald">Sarah M. Mcdonald</name></noRegion><name sortKey="Mcdonald, Sarah M" sort="Mcdonald, Sarah M" uniqKey="Mcdonald S" first="Sarah M." last="Mcdonald">Sarah M. 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